N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Names and Identifiers

Name	PF-3716556
Synonyms	PF03716556 PF-3716556 PF 3716556 PF03716556 PF-03716556 N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa (R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide [N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide] 8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556
CAS	928774-43-0

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Physico-chemical Properties

Molecular Formula	C22H26N4O3
Molar Mass	394.47
Density	1.30
Melting Point	143-145°C
Solubility	DMSO 79 mg/mL Water <1 mg/mL Ethanol 79 mg/mL
Appearance	powder
Color	white to tan
pKa	14.18±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
MDL	MFCD19690947
Use	A highly selective H ,K -ATPase inhibitor that is more potent in acidic conditions.
In vitro study	PF-03716556 is a potent, selective acid-Pump-resistant antagonist that inhibits porcine H in ion-permeation and ion-dense assays
In vivo study	PF-03716556 inhibits gastric acid secretion in rat and dog animal models. PF-03716556 has a long-lasting effect, with a maximum effect of 30 minutes in a single dose, and there is no obvious signal of resistance after 5 consecutive days of injection.

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Risk and Safety

WGK Germany

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Introduction

PF-3716556 is an effective and selective P-CAB potassium ion competitive acid inhibitor. In ion permeation and ion intensive detection, it inhibits pig H ,K -ATPase activity, inhibits gastric acid secretion, has no activity on Na ,K -ATPas, and is used to treat gastroesophageal reflux diseases.

Last Update：2022-10-16 17:41:52

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Reference Information

Biological activity	PF-3716556 is an effective and selective P-CAB potassium ion competitive acid inhibitor. In ion permeation and ion intensive detection, it inhibits pig H ,K -ATPase activity, inhibits gastric acid secretion, has no effect on Na ,K -ATPas, and is used to treat gastroesophageal reflux disease.
Target	Value
H+/K+-ATPase	~6.5(pIC50)

Last Update：2024-04-09 20:02:46

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: PF-3716556 Visit Supplier Webpage Request for quotation
CAS: 928774-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: PF-3716556 Visit Supplier Webpage Request for quotation
CAS: 928774-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa

PF-3716556

CAS: 928774-43-0

Molecular Formula: C22H26N4O3

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Names and Identifiers

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Physico-chemical Properties

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Risk and Safety

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Introduction

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Reference Information

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N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa Request for Quotation

PF-3716556

CAS: 928774-43-0

Molecular Formula: C22H26N4O3

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Names and Identifiers

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Physico-chemical Properties

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Risk and Safety

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Introduction

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa - Reference Information

Supplier List

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa